Genetic Susceptibility and Sleep Disturbance in Black Mothers of Preterm Infants: An Exploratory Study:

SAGE Open Nursing

Shih-YuLee¹ 

关键词: depression;    mental health;    women (reproductive health);    workforce;    stress;    occupational hazards;    quantitative research;    research;   

DOI  :  10.1177/2377960816643326

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Serotonin (5HT) is involved in emotion and sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (short allele) or insertion (long allele) polymorphism in the promoter region of 5HTT (5-HTTLPR) is differentially associated with 5HTT transcription efficiency. Under stressful conditions, the short allele of 5-HTTLPR has been associated with depression and sleep disturbance. Black women are at higher risk for preterm labor and depressive symptoms. Thus, this exploratory study aimed to examine whether depressive symptoms and sleep disturbance in Black mothers would vary as a function of the 5-HTTLPR genotype when they faced the stress of infant hospitalization after preterm birth at early postpartum. A total of 30 Black mothers filled out a battery of questionnaires, including the Perceived Stress Scale, Edinburgh Postnatal Depression Scale, and General Sleep Disturbance Scale. A wrist actigraph was used to assess total sleep time and circadian activity rhythms...

【 授权许可】

CC BY