Основные механизмы первичного бесплодия у женщин репродуктивного возраста с гипоталамической дисфункцией в пубертатном периоде

Acta Biomedica Scientifica

О. Я. Лещенко¹  И. В. Жуковец²  А. В. Аталян² 

[1] ФГБОУ ВО «Амурская государственная медицинская академия» Минздрава России;ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»

关键词: гипоталамическая дисфункция;    эндометрий;    первичное бесплодие;   

DOI  :  10.12737/article_59e8bd5104ac02.59665046

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

Hypothalamic dysfunction is the most common pathology of the puberty and is accompanied by obesity in 39 % of adolescent girls. Obesity is one of the main causes of reproductive function disorders leading to decrease infertility in women. The aim of the study is to assess the gynecological health of reproductive age women with hypothalamic dysfunction in puberty and to determine the mechanisms of the primary infertility formation. We conducted a prospective study of adolescent girls with hypothalamic dysfunction (n = 170) from 2000 to 2013 year. According to the screening criteria, fertility was assessed in 86 women of reproductive age, a comparative characteristic was performed in fertile women (n = 46) and in women with primary infertility (n = 21). PCOS (38.1 %), absence of ayellow body in one of the ovaries (71.4 %), a decrease in serum progesterone by 2 times, an increase in ERa/PGR by 2.3 times and activity of NF-kB by 1.4 times in the endometrium were detected significantly more often in women with primary infertility with hypothalamic dysfunction in puberty in comparison with fertile women. The level of ERa and PGR in the endometrium decreased with increasing activity of NF-kB and BMI. The relationship between the activity of NF-kB and BMI in both study groups was established.

【 授权许可】

CC BY