Development and Evaluation of Floating Pulsatile Drug Delivery System of Meloxicam

Chronicles of Pharmaceutical Science

Naresh Kshirasagar¹  Srilatha Malvey*² 

[1] Vaagdevi College of Pharmacy;Talla Padmavathi College of Pharmacy, India

关键词: Anti-Inflammatory;    Floating Pulsatile;    Chronotherapeutics;    Rheumatoid arthritis;   

DOI  :  

学科分类：医学（综合）

来源: Scientia Ricerca

【 摘 要 】

The main objective of the present research work was to develop chronomodulated, floating-pulsatile drug delivery system to release the drug in distal small intestine part of the GIT in order to achieve chronotherapeutics release of meloxicam without releasing the drug during floating, for the treatment of rheumatoid arthritis, osteoarthritis, spondylitis and to improve the patient compliance. A chronodelivery system, based on biological rhythms, is a state-of-the-art technology for drug delivery to increase safety, efficacy and also improves overall drug performance. The prepared floating-pulsatile tablets of meloxicam consist of different concentrations of a superdisintegrant as a core tablet, containing the active ingredient followed by an erodible membrane of HPMC E5, E15, E50 and topmost covered by buoyant layer consists of HPMC K4M and NaHCO3 (80:20). Developed formulations were evaluated with pre and post compression parameters. On the basis of these evaluation parameters, it was found that optimized immediate release formulation C-3 shows release in 60 min. For pulsatile release core tablet coated with HPMC E 50, P4 shows 7.15 hrs of release, followed by buoyancy layer consists of HPMC K4M and sodium bicarbonate (80:20) showed suitable lag time of 5.15 hrs. Finally, FP4 is considered as an optimized formulation with chronotherapeutic effect.

【 授权许可】

CC BY