Protective Effect of Kolaviron on Cyclophosphamide-Induced Cardiac Toxicity in Rats:

Journal of Evidence-Based Integrative Medicine

Joseph GbengaOmole¹ 

关键词: kolaviron;    cyclophosphamide;    oxidative stress;    cardiotoxicity;    cardiac troponin I;    antioxidant;   

DOI  :  10.1177/2156587218757649

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Background.Cyclophosphamide (CP) is a nitrogen mustard alkylating drug used for the treatment of chronic and acute malignant lymphomas, myeloma, leukemia, neuroblastoma, adenocarcinoma, retinoblastoma, breast carcinoma, and immunosuppressive therapy. Despite its vast therapeutic uses, it is known to cause severe cardiac toxicity. Kolaviron (KV), a Garcinia kola seed extract containing a mixture of flavonoids, is reputed for its antioxidant and membrane stabilizing properties.Objective.This study investigated the protective effect of KV on CP-induced cardiotoxicity in rats.Methods.Thirty rats were used, and they were divided into 6 groups of 5 rats each. Group I received 2 mL/kg propylene glycol orally for 14 days; group II received CP (50 mg/kg/d, intraperitoneally [i.p.]) for 3 days; groups III and IV received 200 and 400 mg/kg/d KV, respectively, orally for 14 days and groups V and VI were pretreated with 200 and 400 mg/kg/d KV, respectively, orally for 14 days followed by CP (50 mg/kg/d, i.p.) for 3 da...

【 授权许可】

CC BY-NC