Multiple animal positioning system shows that socially-reared mice influence the social proximity of isolation-reared cagemates

Communications Biology

Chiharu Tohyama¹  Hideaki Miyauchi²  Hiroshi Oyama³  Waka Ujita⁴  Yusuke Makino⁴  Hiroyuki Mishima⁵  Nozomi Endo⁵  Manabu Makinodan⁶  Masaki Kakeyama⁶  Masaya Fujiwara⁶  Lisa Hashimoto⁶  Mayumi Nishi⁶ 

[1]COCOSNET Ltd., 2-4-29 Kiyokawa, Fukuoka, Japan

[2]Department of Anatomy and Cell Biology, Nara Medical University, Kashihara, Japan

[3]Department of Clinical Information Engineering, Graduate School of Medicine, The University of Tokyo, Hongo, Japan

[4]Laboratory for Systems Neurosciences and Preventive Medicine, Faculty of Human Sciences, Waseda University, Tokorozawa, Japan

[5]Laboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo, Japan

[6]Research Institute for Environmental Medical Sciences, Waseda University, Tokorozawa, Japan

DOI  :  10.1038/s42003-018-0213-5

学科分类：生物科学（综合）

来源: Nature Publishing Group

【 摘 要 】

Social relationships are a key determinant of social behaviour, and disruption of social behaviour is a major symptom of several psychiatric disorders. However, few studies have analysed social relationships among multiple individuals in a group or how social relationships within a group influence the behaviour of members with impaired socialisation. Here, we developed a video-analysis-based system, the Multiple-Animal Positioning System (MAPS), to automatically and separately analyse the social behaviour of multiple individuals in group housing. Using MAPS, we show that social isolation of male mice during adolescence leads to impaired social proximity in adulthood. The phenotype of these socially isolated mice was partially rescued by cohabitation with group-housed (socially-reared) mice, indicating that both individual behavioural traits and those of cagemates influence social proximity. Furthermore, we demonstrate that low reactive behaviour of other cagemates also influence individual social proximity in male mice.

【 授权许可】

CC BY