Notch Signaling Activates Yorkie Non-Cell Autonomously in Drosophila

PLoS One

Sarah E. Woodfield¹  Hillary K. Graves¹  Georg Halder¹  Chih-Chao Yang²  Andreas Bergmann³ 

[1] Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America;Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America;Program in Genes and Development, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

关键词: Notch signaling;    Cloning;    Mutant genotypes;    Apoptosis;    RNA interference;    Drosophila melanogaster;    Imaginal discs;    Eyes;   

DOI  :  10.1371/journal.pone.0037615

学科分类：医学（综合）

来源: Public Library of Science

【 摘 要 】

In Drosophila imaginal epithelia, cells mutant for the endocytic neoplastic tumor suppressor gene vps25 stimulate nearby untransformed cells to express Drosophila Inhibitor-of-Apoptosis-Protein-1 (DIAP-1), conferring resistance to apoptosis non-cell autonomously. Here, we show that the non-cell autonomous induction of DIAP-1 is mediated by Yorkie, the conserved downstream effector of Hippo signaling. The non-cell autonomous induction of Yorkie is due to Notch signaling from vps25 mutant cells. Moreover, activated Notch in normal cells is sufficient to induce non-cell autonomous Yorkie activity in wing imaginal discs. Our data identify a novel mechanism by which Notch promotes cell survival non-cell autonomously and by which neoplastic tumor cells generate a supportive microenvironment for tumor growth.

【 授权许可】

CC BY