PLoS One | |
Notch Signaling Activates Yorkie Non-Cell Autonomously in Drosophila | |
Sarah E. Woodfield1  Hillary K. Graves1  Georg Halder1  Chih-Chao Yang2  Andreas Bergmann3  | |
[1] Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America;Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America;Program in Genes and Development, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America | |
关键词: Notch signaling; Cloning; Mutant genotypes; Apoptosis; RNA interference; Drosophila melanogaster; Imaginal discs; Eyes; | |
DOI : 10.1371/journal.pone.0037615 | |
学科分类:医学(综合) | |
来源: Public Library of Science | |
【 摘 要 】
In Drosophila imaginal epithelia, cells mutant for the endocytic neoplastic tumor suppressor gene vps25 stimulate nearby untransformed cells to express Drosophila Inhibitor-of-Apoptosis-Protein-1 (DIAP-1), conferring resistance to apoptosis non-cell autonomously. Here, we show that the non-cell autonomous induction of DIAP-1 is mediated by Yorkie, the conserved downstream effector of Hippo signaling. The non-cell autonomous induction of Yorkie is due to Notch signaling from vps25 mutant cells. Moreover, activated Notch in normal cells is sufficient to induce non-cell autonomous Yorkie activity in wing imaginal discs. Our data identify a novel mechanism by which Notch promotes cell survival non-cell autonomously and by which neoplastic tumor cells generate a supportive microenvironment for tumor growth.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201904021907537ZK.pdf | 437KB | download |