Importance of Comprehensive Molecular Profiling for Clinical Outcome in Children With Recurrent Cancer

Frontiers in Pediatrics

Olga Østrup¹ 

关键词: recurrent cancer;    children;    molecular profiling;    precision medicine;    clinical intervention;   

DOI  :  10.3389/fped.2018.00114

学科分类：儿科学

来源: Frontiers

【 摘 要 】

Purpose: Pediatric cancers are often difficult to classify and can be complex to treat. To ensure precise diagnostics and identify relevant treatment targets, we implemented comprehensive molecular profiling of consecutive pediatric patients with cancer relapse. We evaluated the clinical impact of extensive molecular profiling by assessing the frequency of identified biological onco-drivers, altered diagnosis, and/or identification of new relevant targeted therapies.

【 授权许可】

CC BY