Science and technology of the emerging nanomedicines in cancer therapy: A primer for physicians and pharmacists:

SAGE Open Medicine

GopalakrishnaPillai¹ 

关键词: Cancer nanomedicines;    approved products;    in clinical development;    multidrug resistance;    targeted delivery;    stimuli-sensitive release;    liposomes;    albumin-bound nanoparticles;    gold nanoshells;   

DOI  :  10.1177/2050312113513759

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Nanomedicine, the medical applications of devices based on nanotechnology, promises an endless range of applications from biomedical imaging to drug and gene delivery. The size range of the nanomaterials is strictly defined as 1–100 nm, although many marketed nanomedicines are in the submicron range of 100–1000 nm. The major advantages of using nanomaterials as a carrier for anticancer agents are the possibility of targeted delivery to the tumor; their physical properties such as optical and magnetic properties, which can be exploited for developing contrast agents for tumor imaging; their ability to hold thousands of molecules of a drug and deliver at the required site and also the ability to overcome solubility and stability issues. Currently, there are several nanotechnology-enabled diagnostic and therapeutic agents undergoing clinical trials and a few already approved by Food and Drug Administration. Targeted delivery of anticancer agents is achieved by exploiting a unique characteristic of the rapidl...

【 授权许可】

CC BY