Полиморфный локус Q223R гена LEPR и ожирение

Acta Biomedica Scientifica

Т. А. Баирова¹  Л. В. Рычкова¹  Е. А. Шенеман¹  К. Д. Иевлева¹ 

[1] ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»

关键词: подростковый возраст;    избыточная масса тела;    ожирение;    полиморфный локус Q223R;    ген LEPR;   

DOI  :  10.12737/23419

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

The problem of overweight and obesity is one of the most urgent health issues in the world. 13 % of girls and 21 % of boys aged 11 suffer from overweight in the Russian Federation. The main causes of pubertal obesity are endocrine pathology, lifestyle and genetic disorders including mutation and polymorphisms of different metabolic pathways. Leptin produced in adipose tissue participates in reproduction regulation, glucose homeostasis, bone formation, etc. These effects are provided by leptin receptors coding LEPR gene. Q223R (rs1137101) polymorphism is associated with an increased serum level of leptin and overweight. There is no exact information about association between this polymorphism and obesity of adolescent females. The objective was to reveal LEPR Q223R polymorphism association between overweight and obesity in adolescent females. 123 Caucasian adolescent females were involved in this study. All samples could be separated into two groups: the girls with normal weight (SDS BM1 ± 1.0; control group), girls with overweight and obesity (SDS BM1 > +1.0-2.0; studied group). Anthropometric measurements (weight, height, waist and hip circumference, body fat percentage) were taken, and genotyping was performed using polymerase chain reaction with electrophoresis detection. G-allele frequency was 43.1 % in control and 40 % in the clinical group. We found no significant differences of the prevalence of polymorphism Q223R between the studied groups (р = 0,862). Furthermore, there was no association between the carriage of AG and GG with weight, BM1, body fat percentage, waist and hip circumference in both groups (р > 0.05). We have not found any association between LEPR Q223R and overweight and obesity in adolescent females.

【 授权许可】

CC BY