miR - 506 : a regulator of chemo-sensitivity through suppression of the RAD51-homologous recombination axis

Cancer Communications

Guoyan Liu¹  Fengxia Xue¹  Wei Zhang² 

[1] Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, P.R. China;Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA

关键词: MicroRNA-506;    Homologous recombination;    Drug sensitivity;    Synthetic lethality;    RAD51;   

DOI  :  10.1186/s40880-015-0049-z

学科分类：肿瘤学

来源: Springer

【 摘 要 】

Ovarian carcinoma is the most lethal gynecologic malignancy. Resistance to platinum is considered the major problem affecting prognosis. Our recent study established that microRNA-506 (miR-506) expression was closely associated with progression-free survival and overall survival in two independent patient cohorts totaling 598 epithelial ovarian cancer cases. Further functional study demonstrated that miR-506 could augment the response to cisplatin and olaparib through targeting RAD51 and suppressing homologous recombination in a panel of ovarian cancer cell lines. Systemic delivery of miR-506 in an orthotopic ovarian cancer mouse model significantly augmented the cisplatin response, thus recapitulating the clinical observation. Therefore, miR-506 plays a functionally important role in homologous recombination and has important therapeutic value for sensitizing cancer cells to chemotherapy, especially in chemo-resistant patients with attenuated expression of miR-506.

【 授权许可】

CC BY