A pilot study on the impact of dopamine, serotonin, and brain-derived neurotrophic factor genotype on long-term functional outcomes after subarachnoid hemorrhage:

SAGE Open Medicine

AnsleyStanfill¹ 

关键词: Subarachnoid hemorrhage;    dopamine;    serotonin;    brain-derived neurotrophic factor;    disability;   

DOI  :  10.1177/2050312117726725

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Objectives:Many that survive an aneurysmal subarachnoid hemorrhage experience lasting physical disability, which might be improved by medications with effects on the dopaminergic, serotonergic, and brain-derived neurotrophic factor neurotransmitter systems. But it is not clear which patients are most likely to benefit from these therapies. The purpose of this pilot study was to explore the relationship of genetic polymorphisms in these pathways with 12-month functional outcomes after aneurysmal subarachnoid hemorrhage.Methods:Subjects were recruited at the time of admission as a part of a larger parent study. Genotypes were generated using the Affymetrix genome-wide human single-nucleotide polymorphism array 6.0. Those within dopaminergic, serotonergic, and brain-derived neurotrophic factor pathways were analyzed for associations with functional outcomes at 12 months post aneurysmal subarachnoid hemorrhage using the Glasgow Outcome Scale and the Modified Rankin Scale.Results:The 154 subjects were 55.8 ± 1...

【 授权许可】

CC BY