Levosimendan in pulmonary hypertension and right heart failure:

Pulmonary Circulation

Mona SahlholdtHansen¹ 

关键词: right heart failure;    levosimendan;    calcium sensitizer;    pulmonary hypertension;    pulmonary arterial hypertension;    congenital heart disease;   

DOI  :  10.1177/2045894018790905

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Pulmonary hypertension is a multifactorial disease with a high morbidity and mortality. Right ventricular function is the most important predictor of morbidity and mortality in patients suffering from pulmonary hypertension, but currently there are no approved treatments directly supporting the failing right ventricle. Levosimendan is a calcium sensitizing agent with inotropic, pulmonary vasodilatory, and cardioprotective properties. Given its pharmacodynamic profile, levosimendan could be a potential novel agent for the treatment of right ventricular failure caused by pulmonary hypertension. The aim of this review is to provide an overview of the current knowledge on the effects of levosimendan in pulmonary hypertension and right heart failure.

【 授权许可】

CC BY