Pathological Outcome in Men with Prostate Cancer Suitable for Active Surveillance after Radical Prostatectomy:

Proceedings of Singapore Healthcare

GraceTan¹ 

关键词: active surveillance;    low risk prostate cancer;    radical prostatectomy;   

DOI  :  10.1177/201010581202100203

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Background:Active surveillance (AS) as a treatment option for low risk prostate cancer is gaining recognition. We evaluate the validity of the AS protocol in our patient population, by defining the risk of undergrading and understaging in their pathology. We also aim to determine more accurate inclusion criteria, in order to improve the prediction of early low risk prostate cancer.Materials and Methods:Data was taken from our institutional prostate cancer registry for all men who underwent radical prostatectomy (RP) between Jan 2000 and June 2009. We determined if any of the patients would have met the University of Toronto's (UoT) AS inclusion criteria and examined their post-operative pathology. The primary end-point was pathological upgrading and upstaging. The individual inclusion factors i.e. preoperative PSA, were tested for statistical significance and better cutoffs. Univariate, multivariate and ROC curves were used in the statistical analysis.Results:216 RPs were performed between January 2000 an...

【 授权许可】

CC BY