Review: Soluble innate immune pattern-recognition proteins for clearing dying cells and cellular components: implications on exacerbating or resolving inflammation:

Innate Immunity

Michael L.Litvack¹ 

关键词: innate immune proteins;    apoptotic cell clearance;    efferocytosis;    programmed cell death;    apoptotic cell receptors;    apoptotic cellular lig;    s;    DNA;    DNA-binding proteins;   

DOI  :  10.1177/1753425910369271

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Soluble innate immune pattern-recognition proteins (sPRPs) identify non-self or altered-self molecular patterns. Dying cells often display altered-self arrays of molecules on their surfaces. Hence, sPRPs are ideal for recognizing these cells and their components. Dying cell surfaces often contain, or allow the access to different lipids, intracellular glycoproteins and nucleic acids such as DNA at different stages of cell death. These are considered as ‘eat me’ signals that replace the native ‘don’t eat me’ signals such as CD31, CD47 present on the live cells. A programmed cell death process such as apoptosis also generates cell surface blebs that contain intracellular components. These blebs are easily released for effective clearance or signalling. During late stages of cell death, soluble components are also released that act as ‘find me’ signal (e.g. LysoPC, nucleotides). The sPRPs such as collectins, ficolins, pentraxins, sCD14, MFG-E8, natural IgM and C1q can effectively identify some of these speci...

【 授权许可】

CC BY