Differentiation therapy: a promising strategy for cancer treatment

Cancer Communications

Quentin Liu¹  Min Yan² 

[1] Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, P.R. China;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China

关键词: Differentiation therapy;    Cancer treatment;    IkB kinase α;   

DOI  :  10.1186/s40880-015-0059-x

学科分类：肿瘤学

来源: Springer

【 摘 要 】

Poor differentiation is an important hallmark of cancer cells, and differentiation therapy holds great promise for cancer treatment. The restoration of IkB kinase α (IKKα) leads to the differentiation of nasopharyngeal carcinoma cells with reduced tumorigenicity. The findings by Yan et al. validate the polycomb protein enhancer of zeste homologue 2 (EZH2) as a target for intervention.

【 授权许可】

CC BY