Is simultaneous pancreas kidney transplant the most cost-effective strategy for type 1 diabetes patients with renal failure?:

Proceedings of Singapore Healthcare

Siew ChinOng¹ 

关键词: Cost-effectiveness;    simultaneous pancreas kidney transplant;    cost-utility analysis;    type 1 diabetes;    renal failure;   

DOI  :  10.1177/2010105815610137

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Introduction:Simultaneous pancreas kidney transplant (SPK) has shown beneficial outcomes in type 1 diabetes patients with renal failure (IDDM-RF). The objective of this study was to assess its cost-effectiveness compared with other treatment strategies for IDDM-RF.Methods:A decision analytic model was developed for IDDM-RF treatment with four possible strategies: deceased donor kidney transplant (DDKT), living donor kidney transplant (LDKT), SPK and dialysis. A cost-utility analysis from the healthcare provider perspective was conducted based on a five-year model. Local data were used whenever possible except for SPK survival variables, wherein data from United Network for Organ Sharing and Scientific Registry of Transplant Recipients were used. Sensitivity analyses were performed to evaluate the impact of uncertainties around key variables.Results:In the baseline analysis, LDKT was the most cost-effective strategy with the lowest cost per quality-adjusted life year gained, i.e. SGD77,068, followed by SPK...

【 授权许可】

CC BY