Особенности взаимосвязей некоторых молекулярных параметров клеток цервикального эпителия с биологическими характеристиками опухолевых клеток в процессе цервикального канцерогенеза

Acta Biomedica Scientifica

Л. Ф. Шолохов¹  Е. В. Каюкова²  Т. Е. Белокриницкая²  П. П. Терешков² 

[1] ФГБНУ «научный центр проблем здоровья семьи и репродукции человека»;ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава России

关键词: короткоцепочечные жирные кислоты;    фактор некроза опухолей-альфа;    апоптоз;    клеточный цикл;    рак шейки матки;   

DOI  :  10.29413/ABS.2018-3.3.22

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

Background. Despite the known trigger and identified risk factors, the screening program developed, many aspects of the pathogenesis of cervical cancer are still being studied. In particular, recently in the literature there are data on the participation of short-chain fatty acids in the tumor process. The aim of the study was to perform a correlation analysis of the level of TNF-A., its soluble sTNF-RI receptor, the spectrum of SCFA and some biological parameters (apoptosis, necrosis, proliferation, cell cycle) in the exocervical cells during dys- and neoplastic transformation. Materials and methods: the laboratory data obtained by us earlier were used to perform the Spearman correlation analysis. The groups of research: IA - the focus of the pre-tumor lesion of exocervix; IB - paradysplastic cells; IIA - locus of cervical cancer; IIB - paraneoplastic cells. Results. The correlation relationships between the parameters studied were multidirectional, determined by the state of the cell (healthy, dysplastic, malignant) and varied within one study, depending on the location in relation to the pathological focus. Conclusions. The revealed interrelations are important for expanding the already available information on cervical carcinogenesis, for discovery of new diagnostic methods and treatment of cervical neoplasia. Summarizing, it is possible to judge the presence of pathogenetic relationships between the processes of cervical carcinogenesis (proliferation, apoptosis, necrosis, modulation of the phases of the cell cycle), the level of short-chain fatty acids and cytokine production at the local level.

【 授权许可】

CC BY