ExtraUterine Growth Restriction (EUGR) in Preterm Infants: Growth Patterns, Nutrition, and Epigenetic Markers. A Pilot Study

Frontiers in Pediatrics

Maria Giulia Tozzi¹ 

关键词: extrauterine growth restriction;    growth patterns;    nutrition;    IC1 methylation;    epigenetics;   

DOI  :  10.3389/fped.2018.00408

学科分类：儿科学

来源: Frontiers

【 摘 要 】

Background/Aims: IntraUterine (IUGR) and ExtraUterine Growth Restriction (EUGR) may induce reprogramming mechanisms, finalized to survive before and after birth. Nutritional factors and other environmental signals could regulate gene expression through epigenetic modification, but the molecular mechanisms involved are not yet well understood. Epigenetic mechanisms could be considered as a bridge between environmental stimuli and long lasting phenotype, acquired during the intrauterine life and the first weeks of life. Our aim was to investigate the relationship between growth patterns, nutritional determinants, and epigenetic pathways.

【 授权许可】

CC BY