Main NK cell receptors and their ligands: regulation by microRNAs

AIMS Allergy and Immunology

Stefano Regis¹ 

[1] 1 Istituto Giannina Gaslini, Genova, Italy 2 Center for Advanced Biomaterials for Healthcare, IIT@CRIB, Istituto Italiano di Tecnologia, Napoli, Italy3 Dipartimento di Medicina Sperimentale, University of Genova, Italy4 Centro di Eccellenza per la Ricerca Biomedica (CEBR), University of Genova, Italy

关键词: NK cells;    microRNAs;    NK receptors;    NK receptor ligands;    TGF-β1;   

DOI  :  10.3934/Allergy.2018.2.98

学科分类：医学（综合）

来源: American Institute of Mathematical Sciences

【 摘 要 】

The NK cells functions are finely tuned by several kinds of inhibitory and activating receptors, whose pattern of expression characterizes different NK subpopulations and varies with the cell activation status. MicroRNAs have an important role in tightly regulating the expression of NK receptors and, analogously, the expression of their ligands in target cells. The relevance of the microRNA-mediated control is highlighted by the dysregulation of these pathways observed in cancer and virus-infected cells. Here we review our current knowledge of the microRNAs involved in the regulation of NK receptors, as well as that of the corresponding cellular ligands.

【 授权许可】

CC BY