Improved Confidence Intervals of a Small Probability from Pooled Testing with Misclassification

Frontiers in Public Health

Chunling Liu¹ 

关键词: confidence intervals;    coverage probability;    exact inference;    pooling;    prevalence;    rare event;    sensitivity;    specificity;   

DOI  :  10.3389/fpubh.2013.00039

学科分类：卫生学

来源: Frontiers

【 摘 要 】

This article concerns construction of confidence intervals for the prevalence of a rare disease using Dorfman’s pooled testing procedure when the disease status is classified with an imperfect biomarker. Such an interval can be derived by converting a confidence interval for the probability that a group is tested positive. Wald confidence intervals based on a normal approximation are shown to be inefficient in terms of coverage probability, even for relatively large number of pools. A few alternatives are proposed and their performance is investigated in terms of coverage probability and length of intervals.

【 授权许可】

CC BY