Immune mediators in the tumor microenvironment of prostate cancer

Cancer Communications

Jian Zhang¹  Yi Lu¹  Jill M. Keller²  Evan T. Keller²  Jinlu Dai²  Hernan Roca³  Laurie K. McCauley³ 

[1] Center for Translational Medicine, Guangxi Medical University, Nanning, P. R. China;Department of Urology and Biointerfaces Institute, University of Michigan, Ann Arbor, USA;Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, USA

关键词: Prostate cancer;    Tumor microenvironment;    Macrophage;    T-regulatory cell;    Th17 cell;    Interleukin-6;    Receptor activator of nuclear factor kappa-B ligand;   

DOI  :  10.1186/s40880-017-0198-3

学科分类：肿瘤学

来源: Springer

【 摘 要 】

Prostate cancer tissue is composed of both cancer cells and host cells. The milieu of host components that compose the tumor is termed the tumor microenvironment (TME). Host cells can be those derived from the tissue in which the tumor originates (e.g., fibroblasts and endothelial cells) or those recruited, through chemotactic or other factors, to the tumor (e.g., circulating immune cells). Some immune cells are key players in the TME and represent a large proportion of non-tumor cells found within the tumor. Immune cells can have both anti-tumor and pro-tumor activity. In addition, crosstalk between prostate cancer cells and immune cells affects immune cell functions. In this review, we focus on immune cells and cytokines that contribute to tumor progression. We discuss T-regulatory and T helper 17 cells and macrophages as key modulators in prostate cancer progression. In addition, we discuss the roles of interleukin-6 and receptor activator of nuclear factor kappa-B ligand in modulating prostate cancer progression. This review highlights the concept that immune cells and cytokines offer a potentially promising target for prostate cancer therapy.

【 授权许可】

CC BY