Analysis of Cell Size Homeostasis at the Single-Cell and Population Level

Frontiers in Physics

Thomas, Philipp¹ 

[1] Department of Mathematics, Imperial College London, United Kingdom

关键词: stochastic individual-based modelling;    Cell size control;    Size distributions;    Homeostasis;    Lineages;    power laws;   

DOI  :  10.3389/fphy.2018.00064

学科分类：物理（综合）

来源: Frontiers

【 摘 要 】

Growth pervades all areas of life from single cells to cell populations to tissues. However, cell size often fluctuates significantly from cell to cell and from generation to generation. Here we present a unified framework to predict the statistics of cell size variations within a lineage tree of a proliferating population. We analytically characterise (i) the distributions of cell size snapshots, (ii) the distribution within a population tree, and (iii) the distribution of lineages across the tree. Surprisingly, these size distributions differ significantly from observing single cells in isolation. In populations, cells seemingly grow to different sizes, typically exhibit less cell-to-cell variability and often display qualitatively different sensitivities to cell cycle noise and division errors. We demonstrate the key findings using recent single-cell data and elaborate on the implications for the ability of cells to maintain a narrow size distribution and the emergence of different power laws in these distributions.

【 授权许可】

CC BY