No Significant Role for Smooth Muscle Cell Mineralocorticoid Receptors in Atherosclerosis in the Apolipoprotein-E Knockout Mouse Model

Frontiers in Cardiovascular Medicine

M. Elizabeth Moss¹ 

关键词: smooth muscle cell;    mineralocorticoid receptor;    atherosclerosis;    inflammation;    apolipoprotein E;    smooth muscle cell phenotype switching;   

DOI  :  10.3389/fcvm.2018.00081

学科分类：心脏病和心血管学

来源: Frontiers

【 摘 要 】

Objective: Elevated levels of the hormone aldosterone are associated with increased risk of myocardial infarction and stroke in humans and increased progression and inflammation of atherosclerotic plaques in animal models. Aldosterone acts through the mineralocorticoid receptor (MR) which is expressed in vascular smooth muscle cells (SMCs) where it promotes SMC calcification and chemokine secretion in vitro. The objective of this study is to explore the role of the MR specifically in SMCs in the progression of atherosclerosis and the associated vascular inflammation in vivo in the apolipoprotein E knockout (ApoE−/−) mouse model.

【 授权许可】

CC BY