Application of Single-Nucleotide Polymorphism-Related Risk Estimates in Identification of Increased Genetic Susceptibility to Cardiovascular Diseases: A Literature Review

Frontiers in Public Health

Szilvia Fiatal¹ 

关键词: genetic screening;    genetic susceptibility;    single-nucleotide polymorphism;    translational research;    cardiovascular diseases;    literature search;   

DOI  :  10.3389/fpubh.2017.00358

学科分类：卫生学

来源: Frontiers

【 摘 要 】

BackgroundAlthough largely preventable, cardiovascular diseases (CVDs) are the biggest cause of death worldwide. Common complex cardiovascular disorders (e.g., coronary heart disease, hypertonia, or thrombophilia) result from a combination of genetic alterations and environmental factors. Recent advances in the genomics of CVDs have fostered huge expectations about future use of susceptibility variants for prevention, diagnosis, and treatment. Our aim was to summarize the latest developments in the field from a public health perspective focusing on the applicability of data on single-nucleotide polymorphisms (SNPs), through a systematic review of studies from the last decade on genetic risk estimating for common CVDs.

【 授权许可】

CC BY