Genetic Variants at 12p11 and 12q24 Are Associated with Breast Cancer Risk in a Chinese Population

PLoS One

Yisha He¹  Hongxia Ma²  Guangfu Jin²  Yanru Wang²  Xiaoxiang Guan²  Hongbing Shen³  Songyu Cao³  Zhenzhen Qin⁴  Zhibin Hu⁴ 

[1] Department of Medical Oncology, Jinling Hospital, Southern Medical University, Nanjing, China;MOE Key Laboratory of Modern Toxicology, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China;Section of Clinical Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China;State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China

关键词: Breast cancer;    Genetic loci;    Genome-wide association studies;    Europe;    Menarche;    Human genetics;    Genetic predisposition;    Chinese people;   

DOI  :  10.1371/journal.pone.0066519

学科分类：医学（综合）

来源: Public Library of Science

【 摘 要 】

Background A recent genome-wide association study (GWAS) has identified three new breast cancer susceptibility loci at 12p11, 12q24 and 21q21 in populations of European descent. However, because of the genetic heterogeneity, it is largely unknown for the role of these loci in the breast cancer susceptibility in the populations of non-European descent.Methodology/Principal Findings Here, we genotyped three variants (rs10771399 at 12p11, rs1292011 at 12q24 and rs2823093 at 21q21) in an independent case–control study with a total of 1792 breast cancer cases and 1867 cancer-free controls in a Chinese population. We found that rs10771399 and rs1292011 were significantly associated with risk of breast cancer with per-allele odds ratios (ORs) of 0.85 (95% confidence interval (CI): 0.76–0.96; P = 0.010) and 0.84 (95% CI: 0.76–0.95; P = 4.50×10−3), respectively, which was consistent with those reported in populations of European descent. Similar effects were observed between ER/PR positive and negative breast cancer for both loci. However, we did not found significant association between rs2823093 and breast cancer risk (OR = 0.97, 95%CI = 0.76–1.24; P = 0.795).Conclusions/Significance Our results indicate that genetic variants at 12p11 and 12q24 may also play an important role in breast cancer development in Chinese women.

【 授权许可】

CC BY