Factors Related to Changes in CD4+ T-Cell Counts over Time in Patients Living with HIV/AIDS: A Multilevel Analysis

PLoS One

Wayner Vieira Souza¹  Heloisa Ramos Lacerda²  Mariana Freitas Aguiar²  Ulisses Ramos Montarroyos³  Maria de Fátima Pessoa Militão Albuquerque³  Demócrito Barros Miranda-Filho⁴  Cibele Comini César⁴  Ricardo Arraes de Alencar Ximenes⁴ 

[1] Departament of Statistics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;Department of Public Health, Research Center Aggeu Magalhães, Osvaldo Cruz Fundation, Recife, Pernambuco, Brazil;Federal University of Pernambuco, Department of Tropical Medicine, Recife, Pernambuco, Brazil;State University of Pernambuco, School of Medical Sciences,Oswaldo Cruz University Hospital, Recife, Pernambuco, Brazil

关键词: Recreational drug use;    Antiretroviral therapy;    HIV;    Habits;    Socioeconomic aspects of health;    T cells;    HIV diagnosis and management;    HIV infections;   

DOI  :  10.1371/journal.pone.0084276

学科分类：医学（综合）

来源: Public Library of Science

【 摘 要 】

Background The measurement of CD4+ T-cell (CD4) counts is a strong predictor of progression to AIDS and a means of monitoring antiviral therapy (ART). The success or failure of controlling virus levels in untreated patients or those taking ART may be associated with treatment adherence, habits, correlated infections unrelated to HIV, cancer, immunosuppressive drugs; as well as socio-economic and psychosocial aspects and access to healthcare. The aim of the present study was to identify, using a multilevel model, the factors related to the variations of CD4 counts over time, in patients living with HIV.Methodology A cohort study was conducted with patients living with HIV, selected from July 2007 to December 2010. Patients were monitored from records of their first CD4 count after being diagnosed with HIV. A multilevel model with 3 levels of aggregation was applied to analyze the associations of predictor variables and the behavior of CD4 over time.Principal Findings A total of 1870 patients were enrolled. The mean number of CD4 at the beginning of the cohort was 393.1 cells/mm3, and there was a mean increase of 1.529 cells/mm3 per month. Patient's age, smoking, use of illicit drugs, hospital treatment, changing doctors and the use of ART, were factors that affected the kinetics of the CD4 count during the follow-up period.Conclusion/Significance The results of this study indicated increased levels of CD4 over time in a cohort of patients living with HIV/AIDS and identified factors that may influence this increase and are liable to intervention.

【 授权许可】

CC BY