Иммуно-генная эффективность антигенного препарата Bacillus anthracis Sternе 34F 2per se и в сочетании с металлосодержащими нанокомпозитами

Acta Biomedica Scientifica

Т. А. Иванова¹  В. И. Дубровина¹  С. А. Витязева¹  О. Б. Колесникова¹  В. Б. Николаев¹  С. В. Лукьянова¹  С. В. Балахонов¹  В. Е. Такайшвили¹  О. В. Юрьева¹ 

[1] ФКУЗ «Иркутский научно-исследовательский противочумный институт» Роспортребнадзора

关键词: сибирская язва;    антигены;    нанокомпозит;    иммуногенность;   

DOI  :  

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

The article presents the research results of immunogenic potency of antigen preparation Bacillus anthracis Sterne 34F on the guinea pig model. It was found that a single inoculation of this preparation, before the contamination of virulent B. anthracis strain, protects 60-80 % of experimental animals. The metal-containing nanocomposites were used to improve the immunogenicity of this antigen preparation. The combined use of antigenic preparation S-2 with argentogalactomannan increases its immunogenic potency and conduces to the survival of experimental animals. Argentogalactomannan exhibits adjuvant properties enhanced the immunogenic features of the S-2 B. anthracis 34F 2Sterne that may indicate its availability as an adjuvant in the construction of chemical vaccines.

【 授权许可】

CC BY