Heat shock proteins and chronic fatigue in primary Sjögren’s syndrome:

Innate Immunity

KjetilBårdsen¹ 

关键词: Chronic fatigue;    innate immunity;    cellular stress;    heat shock proteins;    autoimmune diseases;    Sjögren’s syndrome;   

DOI  :  10.1177/1753425916633236

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Fatigue occurs frequently in patients with cancer, neurological diseases and chronic inflammatory diseases, but the biological mechanisms that lead to and regulate fatigue are largely unknown. When the innate immune system is activated, heat shock proteins (HSPs) are produced to protect cells. Some extracellular HSPs appear to recognize cellular targets in the brain, and we hypothesize that fatigue may be generated by specific HSPs signalling through neuronal or glial cells in the central nervous system. From a cohort of patients with primary Sjögren’s syndrome, 20 patients with high and 20 patients with low fatigue were selected. Fatigue was evaluated with a fatigue visual analogue scale. Plasma concentrations of HSP32, HSP60, HSP72 and HSP90α were measured and analysed to determine if there were associations with the level of fatigue. Plasma concentrations of HSP90α were significantly higher in patients with high fatigue compared with those with low fatigue, and there was a tendency to higher concentrat...

【 授权许可】

CC BY