A case of worsening pulmonary arterial hypertension and pleural effusions by bosutinib after prior treatment with dasatinib:

Pulmonary Circulation

KaranSeegobin¹ 

关键词: pulmonary arterial hypertension;    pleural effusions;    bosutinib;    dasatinib;   

DOI  :  10.1177/2045893217733444

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

A 52-year-old man with a past medical history of chronic myeloid leukemia (CML) in remission developed progressive shortness of breath over a two-month period. He was initially treated with dasatinib for four years, until developing pulmonary arterial hypertension (PAH) with pleural effusions. His symptoms improved after stopping dasatinib. He was then switched to bosutinib for approximately one year, which was then stopped before admission due to worsening shortness of breath. His initial workup showed bilateral pleural effusions with severe PAH and cor pulmonale. He had symptomatic improvement with PAH-specific therapy following discontinuation of the bosutinib.

【 授权许可】

CC BY