Metabolome-Wide Association Study Identifies Multiple Biomarkers that Discriminate North and South Chinese Populations at Differing Risks of Cardiovascular Disease INTERMAP Study

卷:9

Yap, Ivan K. S. ; Brown, Ian J. ; Chan, Queenie ; Wijeyesekera, Anisha ; Garcia-Perez, Isabel ; Bictash, Magda ; Loo, Ruey Leng ; Chadeau-Hyam, Marc ; Ebbeis, Timothy ; De Iorio, Maria ; Maibaum, Elaine ; Zhao, Liancheng ; Kesteloot, Hugo ; Daviglus, Martha L. ; Stamler, Jeremiah ; Nicholson, Jeremy K. ; Elliott, Paul ; Holmes, Elaine

关键词: H-1 NMR;    blood pressure;    epidemiology;    gut microbial cometabolites;    INTERMAP;    metabolome wide association;    metabonomics;    nutrition;   

DOI  :  10.1021/pr100798r

学科分类：内分泌与代谢学

【 摘 要 】

Rates of heart disease and stroke vary markedly between north and south China A H-1 NMR spectroscopy-based metabolome-wide association approach was used to identify urinary metabolites that discriminate between southern and northern Chinese population sam