Gut microbiota and metabolic disorders: how prebiotic can work?

卷:109

Delzenne, Nathalie M. ; Neyrinck, Audrey M. ; Cani, Patrice D.

Catholic Univ Louvain

关键词: Gut microbiota;    Obesity;    Prebiotics;    Inflammation;    Gut peptides;   

DOI  :  10.1017/S0007114512004047

学科分类：食品科学和技术

【 摘 要 】

Experimental data in animals, but also observational studies in obese patients, suggest that the composition of the gut microbiota differs in obese v. lean individuals, in diabetic v. non-diabetic patients or in patients presenting other diseases associated with obesity or nutritional dysbalance, such as non-alcoholic steatohepatitis. In the present review, we will describe how changes in the gut microbiota composition and/or activity by dietary fibres with prebiotic properties, can modulate host gene expression and metabolism. We will evaluate their potential relevance in the management of obesity and related metabolic disturbances, in view of the experimental data and intervention studies published up to date.