Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

卷:5

Gaggini, Melania ; Morelli, Mariangela ; Buzzigoli, Emma ; DeFronzo, Ralph A. ; Bugianesi, Elisabetta ; Gastaldelli, Amalia

CNR

关键词: non-alcoholic fatty liver (NAFLD);    steatosis;    visceral fat;    lipotoxicity;    insulin resistance;    free fatty acids;    dyslipidemia;    cardiometabolic risk;   

DOI  :  10.3390/nu5051544

学科分类：食品科学和技术

【 摘 要 】

Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol abuse. Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty acids (FFAs). The increase of FFAs induces mitochondrial dysfunction and development of lipotoxicity. Moreover, in subjects with NAFLD, ectopic fat also accumulates as cardiac and pancreatic fat. In this review we analyzed the mechanisms that relate NAFLD with metabolic syndrome and dyslipidemia and its association with the development and progression of cardiovascular disease.