Higher Cardiovascular Risk in Common Variable Immunodeficiency and X-Linked Agammaglobulinaemia Patients

卷:66

Vieira, Daniele Goncalves ; Costa-Carvalho, Beatriz Tavares ; Hix, Sonia ; da Silva, Rosangela ; Correia, Milena S. G. ; Saccardo Sarni, Roseli Oselka

Rua Rene Zamlutti 94 Ap 52 Vila Mariana

关键词: Common variable immunodeficiency;    Agammaglobulinaemia;    Apo A-I;    Dyslipidaemia;    Nutritional status;    Inflammation;   

DOI  :  10.1159/000435818

学科分类：食品科学和技术

【 摘 要 】

Introduction: Common variable immunodeficiency and X-linked agammaglobulinaemia are primary immunodeficiencies classified as antibody deficiencies, and they both result in hypogammaglobulinaemia. Objective: Evaluate the lipid profile and other cardiovascular risk biomarkers in CVID and XLA patients. Methods: In total, 24 patients and 12 healthy controls matched by age and gender were included in the study. We evaluated anthropometric measurements, and seric total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), apo A-I, small dense LDL (sdLDL), C-reactive protein (CRP), and tumour necrosis factor alpha (TNF-alpha), myeloperoxidase (MPO), cholesteryl ester transfer protein (CETP), and lecithin cholesterol acyltransferase (LCAT) were assessed. Results: CRP (p = 0.008) and TNF-alpha (p < 0.001) concentrations were significantly higher, whereas HDL-c (p = 0.025) and apo A-I (p = 0.013) levels were significantly lower in patients than in the controls. In the patient group, a negative and significant correlation was observed between HDL-c and TNF-alpha (r = -0.406; p = 0.049) and between HDL-c and TG (r = -0.641; p = 0.001). Conclusion: Common variable immunodeficiency and X-linked agammaglobulinaemia patients presented themselves with increased inflammatory markers associated with a decreased HDL-c and apo A-I levels, which can predispose to a high cardiovascular risk. (C) 2015 S. Karger AG, Basel