Antibacterial oleanane-type triterpenoids from pericarps of Akebia trifoliata

卷:168

Wang, Jing ; Ren, Hui ; Xu, Qiao-Lin ; Zhou, Zhong-Yu ; Wu, Ping ; Wei, Xiao-Yi ; Cao, Yong ; Chen, Xue-Xiang ; Tan, Jian-Wen

Chinese Acad Sci

关键词: Akebia trifoliata;    Lardizabalaceae;    Triterpenoids;    Antimicrobial activity;   

DOI  :  10.1016/j.foodchem.2014.07.105

学科分类：食品科学和技术

【 摘 要 】

Three new oleanane triterpenoids, 2 alpha,3 beta,29-trihydroxyolean-12-en-28-oic acid (1), 2 alpha,3 beta-dihydroxy-23-oxo-olean-12-en-28-oic acid (2) and 2 alpha,3 beta,21 beta,22 alpha-tetrahydroxyolean-12-en-28,29-dioic acid (3), and ten known ones, maslinic acid (4), arjunolic acid (5), oleanolic acid (6), 3-epi-oleanolic acid (7), stachlic acid A (8), serratagenic acid (9), gypsogenic acid (10), 2 alpha,3 beta-dihydroxyol-ean-13(18)-en-28-oic acid (11), mesembryanthemoidigenic acid (12) and 12 alpha-hydroxy-delta-lactone (13), were isolated from the pericarps of Akebia trifoliata, a new valued fruit crop in China. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 8, 10, 11 and 13 were isolated for the first time from the genus Akebia. All the compounds were tested for their antimicrobial activity against five bacterial strains. Compounds 4, 6 and 11 showed significant antibacterial activity toward all the assayed microorganisms with MIC values ranging from 0.9 to 15.6 mu g/mL, which were close or even more potent than the reference compound Kanamycin (MIC values ranging from 1.9 to 3.9 mu g/mL). (C) 2014 Elsevier Ltd. All rights reserved.