Maternal Supplementation With Natural or Synthetic Vitamin E and Its Levels in Human Colostrum

卷:60

Clemente, Heleni A. ; Ramalho, Heryka M. M. ; Lima, Mayara S. R. ; Grilo, Evellyn C. ; Dimenstein, Roberto

关键词: all-rac-alpha-tocopherol;    maternal supplementation;    RRR-alpha-tocopherol;    vitamin E;   

DOI  :  10.1097/MPG.0000000000000635

学科分类：食品科学和技术

【 摘 要 】

Objectives: Newborns are considered a high-risk group for vitamin E deficiency. Breast milk is a source of alpha-tocopherol (alpha-TOH), a form of vitamin E that prevents deficiency. The present study aimed to assess whether supplementation with a natural or synthetic form of alpha-TOH, in addition to maternal sources of vitamin E, would increase the concentration of alpha-TOH in colostrum. Methods: A total of 109 healthy lactating women were recruited from a Brazilian public maternity clinic and randomized into 3 groups: control without supplementation (n = 36), natural alpha-TOH supplementation (n = 40), and synthetic alpha-TOH supplementation (n = 33). Blood and colostrum samples were collected before and after supplementation to check the nutritional status of these women by high-performance liquid chromatography. The Kruskal-Wallis test was applied for independent samples, and Tukey test was used for 2-way analysis of the averages of the groups. The baseline nutritional status of vitamin E of all of the lactating women enrolled in the trial was considered adequate. Results: Women who received supplementation had higher concentrations of alpha-TOH in colostrum than the control group, with 57% and 39% increases in women supplemented with the natural and synthetic forms of alpha-TOH, respectively. Conclusions: Supplementation with both forms of alpha-TOH increased vitamin E concentrations in colostrum; however, the natural form was more efficient in increasing the levels.