Mechanistic Effects of Calcitriol in Cancer Biology

卷:7

Diaz, Lorenza ; Diaz-Munoz, Mauricio ; Cristina Garcia-Gaytan, Ana ; Mendez, Isabel

关键词: calcitriol;    cancer;    inflammation;    vitamin D deficiency;    oncogenesis;   

DOI  :  10.3390/nu7065020

学科分类：食品科学和技术

【 摘 要 】

Besides its classical biological effects on calcium and phosphorus homeostasis, calcitriol, the active vitamin D metabolite, has a broad variety of actions including anticancer effects that are mediated either transcriptionally and/or via non-genomic pathways. In the context of cancer, calcitriol regulates the cell cycle, induces apoptosis, promotes cell differentiation and acts as anti-inflammatory factor within the tumor microenvironment. In this review, we address the different mechanisms of action involved in the antineoplastic effects of calcitriol.