Antinociceptive and anti-inflammatory activities of a pomegranate (Punica granatum L.) extract rich in ellagitannins

卷:66

Gonzalez-Trujano, Maria Eva ; Pellicer, Francisco ; Mena, Pedro ; Moreno, Diego A. ; Garcia-Viguera, Cristina

关键词: Anti-inflammatory;    antinociception;    anthocyanin;    ellagitannin;    formalin test;    gastroprotection;   

DOI  :  10.3109/09637486.2015.1024208

学科分类：食品科学和技术

【 摘 要 】

Pomegranate (Punica granatum L.) has been used for centuries for the treatment of inflammatory diseases. However, there is a lack of comprehensive information focused on the properties of a certain pomegranate (poly) phenolic profile to cure pain and gastric injury induced by anti-inflammatory drugs. This study investigated the systemic effects of different doses of a HPLC-characterized pomegranate extract on the formalin-induced nociceptive behavior in mice. The effect of the extract against gastric injury caused by non-steroidal anti-inflammatory drugs and ethanol was also assessed. Pomegranate reduced nociception in both phases of the formalin test, suggesting central and peripheral activities to inhibit nociception. Indomethacin-induced gastric injury was not produced in the presence of pomegranate, which also protected against ethanol-induced gastric lesions. The present results reinforce the benefits of pomegranate (poly) phenolics in the treatment of pain as well as their anti-inflammatory properties.