Association between vitamin A, retinol intake and blood retinol level and gastric cancer risk: A meta-analysis

卷:34

Wu, Yihua ; Ye, Yao ; Shi, Yu ; Li, Peiwei ; Xu, Jinming ; Chen, Kun ; Xu, Enping ; Yang, Jun

关键词: Vitamin A;    Retinol;    Gastric cancer;    Incidence;    Meta-analysis;   

DOI  :  10.1016/j.clnu.2014.06.007

学科分类：食品科学和技术

【 摘 要 】

Background & aims: The association between dietary vitamin A, retinol intake and blood retinol level and gastric cancer risk has been investigated by many studies. However, the results of these studies were controversial. The aim of our study was to systematically assess this issue. Methods: PUBMED and EMBASE were searched, supplemented with manual-screening for relevant publications. Meta-analyses were performed to evaluate the association between vitamin A, retinol dietary intake or blood retinol level and gastric cancer risk. Results: Thirty-one studies were included in this meta-analysis. Comparing the highest with the lowest categories, vitamin A intake significantly reduced gastric cancer risk (pooled RR = 0.66, 95% Cl: 0.52 -0.84), whereas a marginally inverse association was found between retinol intake (pooled RR = 0.94, 95% CI: 0.87-1.03) or blood retinol level (pooled RR = 0.87, 95% CI: 0.73-1.05) and gastric cancer risk. Interestingly, the results of subgroup analysis indicated that high vitamin A intake and blood retinol level were associated with reduced gastric cancer risk in Western countries, while a marginally inverse association was found between retinol and gastric cancer risk in Western countries. Conclusions: Vitamin A intake was inversely associated with gastric cancer risk, while no significant association was found with retinol intake or blood retinal level. (C) 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.