Effects of long-term consumption of standard diets including glucose-lysine model glycated compounds on the antioxidant status of adult rats

卷:183

Pastoriza, Silvia ; Angel Rufian-Henares, Jose ; Delgado-Andrade, Cristina

关键词: Model Maillard compounds;    Global antioxidant response;    CAT;    SOD;    GPx;    GSH;   

DOI  :  10.1016/j.foodchem.2015.03.038

学科分类：食品科学和技术

【 摘 要 】

Our purpose was to evaluate the uptake of antioxidant capacity (AC) in rats fed long-term a diet containing commonly consumed Maillard reaction products (MRPs) from the glucose-lysine system. The effects on the oxidative status of liver, biceps brachii muscle and serum were also tested. The presence of model MRPs in the diet, especially melanoidins, led to a significantly higher intake (24.0 mu mol Trolox/day), faecal excretion (0.604 mu mol Trolox/day), and uptake (23.4 mu mol Trolox/day) of AC, although the uptake rate remained stable compared to the control group (97.5%). Consumption of the assayed MRPs did not affect the hepatic antioxidant defence while some positive modifications, like an increase in glutathione peroxidase, were detected in muscle (29%) and serum (400%). This pointed to an improved antioxidant capacity. Despite the interesting findings for these specific MRPs, attention must be paid to the overall consumption of MRPs from different sources in a conventional diet, due to their implications in the development/advance of many disorders. (C) 2015 Elsevier Ltd. All rights reserved.