Iron Absorption from an Intrinsically Labeled Lentil Meal Is Low but Upregulated in Women with Poor Iron Status

卷:145

DellaValle, Diane M. ; Glahn, Raymond P. ; Shaff, Jon E. ; O'Brien, Kimberly

关键词: pulses;    iron;    bioavailability;    lentils;    absorption;    non-heme;   

DOI  :  10.3945/jn.115.217273

学科分类：食品科学和技术

【 摘 要 】

Background: Low iron absorption from important staple foods may contribute to iron deficiency in developing countries. To date, few studies have examined the iron bioavailability of pulse crops as commonly prepared and consumed by humans. Objective: The objectives were to characterize the iron absorption from a test meal of intrinsically labeled Fe-57 lentils prepared as dal, to compare the bioavailability of iron from Fe-57 in dal with that observed for a reference dose of Fe-58 as ferrous sulfate, and to assess associations between iron absorption and iron status indicators. Methods: This crossover study included 19 nonpregnant women (n= 6 anemic; hemoglobin: <12.0 g/dL) who consumed 2 test meals on consecutive days in a counter-balanced order, ferrous sulfate (7 mg FeSO4 plus 1 mg Fe-58) and 330 g dal (lentils enriched to 85.1% with Fe-57, 8 mg native Fe-57). Iron absorption was determined by analyzing blood samples taken 14 d after dosing with the use of magnetic sector thermal ionization mass spectrometry. Results: We found that the mean iron absorption from the dal was 2.20% +/- 3.40% and was significantly lower than the 23.6% +/- 13.2% observed from the same iron load given as ferrous sulfate (P < 0.001). Absorption of non-heme iron from dal and from ferrous sulfate was inversely associated with serum ferritin (SF; r= 0.50, P= 0.05 and r= 0.81, P< 0.001, respectively) and serum hepcidin (r= 0.45, P= 0.05 and r= 0.60, P= 0.007, respectively). Anemic women absorbed more iron from either source (1.20% from dal, P= 0.10; 18.3% from ferrous sulfate, P= 0.001) compared with women who were iron replete. Conclusions: Iron absorption from the dal was low overall but upregulated in anemic women. Both SF and hepcidin were inversely associated with iron absorption from both a supplemental and a food-based non-heme iron source in nonanemic and anemic women.