Infants Fed a Lower Calorie Formula With 2 ' FL Show Growth and 2 ' FL Uptake Like Breast-Fed Infants

卷:61

Marriage, Barbara J. ; Buck, Rachael H. ; Goehring, Karen C. ; Oliver, Jeffery S. ; Williams, Jennifer A.

Abbott Nutr

关键词: galactooligosaccharides;    growth;    human milk oligosaccharides;    infant formula;    tolerance;   

DOI  :  10.1097/MPG.0000000000000889

学科分类：食品科学和技术

【 摘 要 】

Objectives:The aim of the present study was to examine the growth and tolerance of infants fed infant formulas with a caloric density closer to human milk (HM) supplemented with human milk oligosaccharides (HMOs) and to study uptake of the HMOs.Methods:A prospective, randomized, controlled, growth and tolerance study was conducted in healthy, singleton infants (birth weight 2490 g), who were enrolled by day of life (DOL) 5. Formula-fed infants were randomized to 1 of 3 formulas with a caloric density of 64.3 kcal/dL. Each formula contained galactooligosaccharides, and the 2 experimental formulas contained varying levels (0.2 and 1.0 g/L) of the HMO 2-fucosyllactose (2FL). The 3 formula groups were compared with an HM-fed reference group. Infants were exclusively fed either formula (n=189) or HM (n=65) from enrollment to 119 DOL. 2FL was measured in the blood and urine collected from a subset of infants at DOL 42 and 119, and in HM collected from breast-feeding mothers at DOL 42.Results:There were no significant differences among any groups for weight, length, or head circumference growth during the 4-month study period. All of the formulas were well tolerated and comparable for average stool consistency, number of stools per day, and percent of feedings associated with spitting up or vomit. 2FL was present in the plasma and urine of infants fed 2FL, and there were no significant differences in 2FL uptake relative to the concentration fed.Conclusions:This is the first report of infants fed 2FL-fortified formulas with a caloric density similar to HM. Growth and 2FL uptake were similar to those of HM-fed infants.