期刊论文详细信息
卷:27 | |
Postprandial insulin action relies on meal composition and hepatic parasympathetics: dependency on glucose and amino acids Meal, parasympathetics & insulin action | |
Afonso, Ricardo A. ; Gaspar, Joana M. ; Lamarao, Iva ; Wayne Lautt, W. ; Paula Macedo, M. | |
Univ Nova Lisboa | |
关键词: Insulin action; Insulin sensitivity; Meal composition; Parasympathetic nerves; Protein intake; Glucose; Nutritional modulation of insulin sensitivity; | |
DOI : 10.1016/j.jnutbio.2015.08.023 | |
学科分类:食品科学和技术 | |
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【 摘 要 】
Insulin sensitivity (IS) increases following a meal. Meal composition affects postprandial glucose disposal but still remains unclear which nutrients and mechanisms are involved. We hypothesized that gut-absorbed glucose and amino acids stimulate hepatic parasympathetic nerves, potentiating insulin action. Male Sprague-Dawley rats were 24 h fasted and anesthetized. Two series of experiments were performed. (A) IS was assessed before and after liquid test meal administration (10 ml.kg(-1), intraenteric): glucose + amino acids + lipids (GAL, n=6); glucose (n=5); amino acids (n=5); lipids (n=3); glucose + amino acids (GA, n=9); amino acids + lipids (n=3); and glucose + lipids (n=4). (B) Separately, fasted animals were submitted to hepatic parasympathetic denervation (DEN); IS was assessed before and after GAL (n=4) or GA administration (n=4). (A) Both GAL and GA induced significant insulin sensitization. GAL increased IS from 97.9+/-6.2 mg glucose/kg bw (fasting) to 225.4+/-183 mg glucose/kg bw (P<0.001; 143.6+/-26.0% potentiation of IS); GA increased IS from 109.0+/-6.6 to 240.4+/-18.0 mg glucose/kg bw (P<0.001; 123.1+/-13.4% potentiation). None of the other meals potentiated IS. (B) GAL and GA did not induce a significant insulin sensitization in DEN animal. To achieve maximal insulin sensitization following a meal, it is required that gut-absorbed glucose and amino acids trigger a vagal reflex that involves hepatic parasympathetic nerves. (C) 2015 Elsevier Inc. All rights reserved.【 授权许可】
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