Endemic fluorosis in Henan province, China: ER alpha gene polymorphisms and reproductive hormones among women

卷:25

Zhou, Guo-Yu ; Ren, Li-Jun ; Hou, Jia-Xiang ; Cui, Liu-Xin ; Ding, Zhong ; Cheng, Xue-Min ; Zhu, Jing-Yuan ; Cui, Rui-Rui ; Ba, Yue

Zhengzhou Univ

关键词: fluoride;    ER alpha;    gene polymorphism;    women;    reproductive hormones;   

DOI  :  10.6133/apjcn.062016.01

学科分类：食品科学和技术

【 摘 要 】

Background and Objectives: The aim of this study was to explore the influence of fluoride exposure and ER alpha gene polymorphisms on reproductive hormone concentrations of women in accordance with endemic fluorosis residence. Methods and Study Design: A cross sectional study was conducted in Tongxu county, Henan Province, China. A total of 679 women were recruited using cluster sampling and each subject provided fasting blood and an associated urine sample. We measured the concentrations of serum gonadotropin releasing hormone (GnRH), follicle-stimulating hormone, luteinizing hormone, and estradiol and urinary fluoride. Results: In the defluoridation project group (DFPG), serum GnRH was lower in women carrying C/C genotype compared to in those carrying C/T and T/T genotypes of ER alpha gene rs3798577 (p<0.05). In the endemic fluorosis group (EFG), serum GnRH was lower in women carrying Pp genotype compared to in those carrying PP and pp genotypes of ER alpha PvuII (p<0.05). Serum GnRH in women from EFG who carried Pp, pp, Xx and xx genotypes in ER alpha gene PvuII and XbaI was lower than in those in the control group (CG) who carried same genotypes (p<0.05). Furthermore, serum GnRH in women from EFG was significantly lower than in those in CG, regardless of whether the women were carrying C/C, C/T or T/T genotypes of ER alpha rs3798577 (p<0.05). Serum estradiol concentrations in EFG were significantly lower than in CG when the women were carrying the Pp, Xx and T/T genotypes in ER alpha gene (p<0.05). Conclusion: Interaction of ER alpha gene and fluoride exposure may influence women's serum reproductive hormone concentrations.