Bioavailability and biodistribution of nanodelivered lutein

卷:192

Kamil, Alison ; Smith, Donald E. ; Blumberg, Jeffrey B. ; Astete, Carlos ; Sabliov, Cristina ; Chen, C. -Y. Oliver

Tufts Univ

关键词: Bioavailability;    Caco-2 cells;    Lutein (PubChem CID: 5281243);    Nanoparticles;    Poly(lactic-co-glycolic acid) (PubChem CID: 23111554);    Rats;   

DOI  :  10.1016/j.foodchem.2015.07.106

学科分类：食品科学和技术

【 摘 要 】

The aim of the study was to evaluate the ability of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NP) to enhance lutein bioavailability. The bioavailability of free lutein and PLGA-NP lutein in rats was assessed by determining plasma pharmacokinetics and deposition in selected tissues. Lutein uptake and secretion was also assessed in Caco-2 cells. Compared to free lutein, PLGA-NP increased the maximal plasma concentration (Cm) and area under the time-concentration curve in rats by 54.5- and 77.6-fold, respectively, while promoting tissue accumulation in the mesenteric fat and spleen. In comparison with micellized lutein, PLGA-NP lutein improved the C-max in rat plasma by 15.6-fold and in selected tissues by >3.8-fold. In contrast, PLGA-NP lutein had a lower uptake and secretion of lutein in Caco-2 cells by 10.0- and 50.5-fold, respectively, compared to micellized lutein. In conclusion, delivery of lutein with polymeric NP may be an approach to improve the bioavailability of lutein in vivo. (C) 2015 Elsevier Ltd. All rights reserved.