Molecular imprinting method for fabricating novel glucose sensor: Polyvinyl acetate electrode reinforced by MnO2/CuO loaded on graphene oxide nanoparticles

卷:194

Farid, Mohammad Masoudi ; Goudini, Leila ; Piri, Farideh ; Zamani, Abbasali ; Saadati, Fariba

Univ Zanjan

关键词: Enzyme free sensor;    Cyclic voltammetry;    Clinical chemistry;    Nanocomposite;   

DOI  :  10.1016/j.foodchem.2015.07.128

学科分类：食品科学和技术

【 摘 要 】

An enzyme free glucose sensor was prepared by a molecular imprinting method (MIP). The procedure was developed by in situ preparation of a new polyvinyl acetate (PVA) electrode reinforced by MnO2/CuO loaded on graphene oxide (GO) nanoparticles (PVA/MnO2@GO/CuO). The nanocomposite was modified in the presence of glucose and then imprinted. A carbone paste method with voltammetry was used in the fabrication of the sensor from prepared MIP nanocomposite. PVA/MnO2@GO/CuO electrode was characterized by X-ray diffraction, FT-IR spectroscopy and scanning electron microscopy. Electrocatalytic activity of the electrode toward glucose oxidation was then investigated by cyclic voltammetry in alkaline medium. The results show that the response of PVA/MnO2@GO/CuO MIP is much higher than PVA/MnO2@GO/CuO non-imprinted electrode toward glucose oxidation. The detection limit was 53 mu M, and the sensor responses are linear for concentrations from 0.5 to 4.4 mM. Relative standard deviations for intra- and inter-day determination were less than 6.0%. The relative recoveries for different samples were 96%. (C) 2015 Elsevier Ltd. All rights reserved.