Maternal Caffeine Intake During Pregnancy, Early Growth, and Body Fat Distribution at School Age

卷:24

Voerman, Ellis ; Jaddoe, Vincent W. V. ; Gishti, Olta ; Hofman, Albert ; Franco, Oscar H. ; Gaillard, Romy

Univ Med Ctr

DOI  :  10.1002/oby.21466

学科分类：食品科学和技术

【 摘 要 】

Objective: The associations of maternal caffeine intake during pregnancy with offspring growth patterns and body fat and insulin levels at school age were examined. Methods: In a population-based birth cohort among 7,857 mothers and their children, maternal caffeine intake during pregnancy was assessed by questionnaires. Growth characteristics were measured from birth onward. At 6 years, body fat and insulin levels were measured. Results: Compared to children whose mothers consumed <2 units of caffeine per day during pregnancy (1 unit of caffeine is equivalent to 1 cup of coffee (90 mg caffeine)), those whose mothers consumed >= 6 units of caffeine per day tended to have a lower weight at birth, higher weight gain from birth to 6 years, and higher body mass index from 6 months to 6 years. Both children whose mothers consumed 4-5.9 and >= 6 units of caffeine per day during pregnancy tended to have a higher childhood body mass index and total body fat mass. Only children whose mothers consumed >= 6 units of caffeine per day had a higher android/gynoid fat mass ratio. Conclusions: These results suggest that high levels of maternal caffeine intake during pregnancy are associated with adverse offspring growth patterns and childhood body fat distribution.