期刊论文详细信息
卷:19
The effect of providing lipid-based nutrient supplements on morbidity in rural Malawian infants and young children: a randomized controlled trial
Bendabenda, Jaden ; Alho, Lotta ; Ashorn, Ulla ; Cheung, Yin Bun ; Dewey, Kathryn G. ; Vosti, Stephen A. ; Phuka, John ; Maleta, Kenneth ; Ashorn, Per
Univ Tampere
关键词: Lipid-based nutrient supplements;    Infectious disease morbidity;    Iron;    Children;    Low-income countries;   
DOI  :  10.1017/S1368980016000331
学科分类:食品科学和技术
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【 摘 要 】
Objective Safety of home fortificants in children is uncertain in areas where infections are common. We tested the hypothesis that provision of lipid-based nutrient supplements (LNS) containing Fe does not increase infectious morbidity in children. Design Randomized controlled trial. Infants were randomised to receive 10, 20 or 40 g LNS/d; or no supplement until age 18 months. All LNS contained 6 mg Fe/d. Morbidity outcomes (serious adverse events, non-scheduled visits and guardian-reported morbidity episodes) were compared between control and intervention groups using a non-inferiority margin of 20 %. Setting Namwera and Mangochi catchment areas in rural Malawi. Subjects Infants aged 6 months (n 1932). Results The enrolled 1932 infants contributed 1306 child-years of follow-up. Baseline characteristics were similar across groups. Compared with the control group, the relative risk (95 % CI) of serious adverse events was 071 (048, 107), 067 (048, 095) and 091 (066, 125) in 10, 20 and 40 g LNS/d groups, respectively. The incidence rate ratio (95 % CI) of non-scheduled visits due to malaria was 110 (088, 137), 108 (089, 131) and 121 (100, 146), and of guardian-reported morbidity episodes was 104 (096, 111), 103 (097, 110) and 104 (097, 110), in the respective LNS groups. Conclusions Provision of 10 and 20 g LNS/d containing 6 mg Fe/d did not increase morbidity in the children. Provision of 40 g LNS/d did not affect guardian-reported illness episodes but may have increased malaria-related non-scheduled visits.
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