卷:51 | |
4-Hydroxyderricin, as a PPAR gamma Agonist, Promotes Adipogenesis, Adiponectin Secretion, and Glucose Uptake in 3T3-L1 Cells | |
Li, Yongjia ; Goto, Tsuyoshi ; Yamakuni, Kanae ; Takahashi, Haruya ; Takahashi, Nobuyuki ; Jheng, Huei-Fen ; Nomura, Wataru ; Taniguchi, Masahiko ; Baba, Kimiye ; Murakami, Shigeru ; Kawada, Teruo | |
Kyoto Univ | |
关键词: 4-Hydroxyderricin; Angelica keiskei; Adipocyte; Adiponectin; Glucose uptake; PPAR gamma; | |
DOI : 10.1007/s11745-016-4154-9 | |
学科分类:食品科学和技术 | |
【 摘 要 】
Adipocyte differentiation plays a pivotal role in maintaining the production of small-size adipocytes with insulin sensitivity, and impaired adipogenesis is implicated in insulin resistance. 4-Hydroxyderricin (4-HD), a phytochemical component of Angelica keiskei, possesses diverse biological properties such as anti-inflammatory, antidiabetic, and antitumor. In the present study, we investigated the effects of 4-HD on adipocyte differentiation. 4-HD promoted lipid accumulation in 3T3-L1 cells, upregulated both peroxisome proliferator-activated receptor (PPAR)-gamma mRNA and protein expression, and acted as a ligand for PPAR gamma in the luciferase assay. Moreover, 4-HD increased the mRNA and protein expression levels of adiponectin. Additionally, it promoted insulin-dependent glucose uptake into 3T3-L1 adipocytes and increased Akt phosphorylation and glucose transporter (GLUT) 4 mRNA expression. In summary, these findings suggest that 4-HD, which promoted adipogenesis and insulin sensitivity in 3T3-L1 cells, might be a phytochemical with potent insulin-sensitizing effects.
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