Maternal serum retinal and beta-carotene concentrations and neonatal bone mineralization: results from the Southampton Women's Survey cohort

卷:104

Handel, Mina N. ; Moon, Rebecca J. ; Titcombe, Philip ; Abrahamsen, Bo ; Heitmann, Berit L. ; Calder, Philip C. ; Dennison, Elaine M. ; Robinson, Sian M. ; Godfrey, Keith M. ; Inskip, Hazel M. ; Cooper, Cyrus ; Harvey, Nicholas C.

Univ Oxford

关键词: bone development;    epidemiology;    pregnancy;    vitamin A;    retinol;    beta-carotene;   

DOI  :  10.3945/ajcn.116.130146

学科分类：食品科学和技术

【 摘 要 】

Background: Studies in older adults and animals have suggested contrasting relations between bone health and different vitamin A compounds. To our knowledge, the associations between maternal vitamin A status and offspring bone development have not previously been elucidated. Objective: We examined the associations between maternal serum retinol and beta-carotene concentrations during late pregnancy and offspring bone mineralization assessed at birth with the use of dual-energy X-ray absorptiometry. Design: In the Southampton Women's Survey mother-offspring birth cohort, maternal health, lifestyle, and diet were assessed pre-pregnancy and at 11 and 34 wk of gestation. In late pregnancy, maternal serum retinol and beta-carotene concentrations were measured. Offspring total body bone mineral density (BMD), bone mineral content (BMC), and bone area (BA) were measured within 2 wk after birth. Results: In total, 520 and 446 mother-offspring pairs had measurements of maternal serum retinol and beta-carotene, respectively. Higher maternal serum retinol in late pregnancy was associated with lower offspring total body BMC = 0.10 SD/SD; 95% CI: 0.19, 0.02; P = 0.020) and BA (p = 0.12 SD/SD; 95% CI: 0.20, 0.03; P = 0.009) but not BMD. Conversely, higher maternal serum beta-carotene concentrations in late pregnancy were associated with greater total body BMC = 0.12 SD/SD; 95% CI: 0.02, 0.21; P = 0.016) and BA (beta = 0.12 SD/SD; 95% CI: 0.03, 0.22; P = 0.010) but not BMD. Conclusions: Maternal serum retinol and beta-carotene concentrations had differing associations with offspring bone size and growth at birth: retinol was negatively associated with these measurements, whereas beta-carotene was positively associated. These findings highlight the need for further investigation of the effects of maternal retinol and carotenoid status on offspring bone development.