期刊论文详细信息
卷:104
Maternal protein intake during pregnancy and linear growth in the offspring
Switkowski, Karen M. ; Jacques, Paul F. ; Must, Aviva ; Kleinman, Ken P. ; Gillman, Matthew W. ; Oken, Emily
Tufts Univ
关键词: linear growth;    pregnancy;    protein;    cohort;    maternal diet;    programming;   
DOI  :  10.3945/ajcn.115.128421
学科分类:食品科学和技术
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【 摘 要 】

Background: Observational and experimental evidence demonstrates that protein intake in infancy programs linear growth. To our knowledge, few studies have examined prenatal maternal protein intake. Objective: Our objective was to examine associations of maternal protein intake during pregnancy with offspring linear growth. Design: We analyzed data from 1961 mother-child pairs in Project Viva. We assessed first- and second-trimester diet with the use of food frequency questionnaires and analyzed protein intake as grams per kilogram prepregnancy weight per day. We used research measures of offspring length at birth and in infancy (similar to 6 mo), early childhood (similar to 3 y), and midchildhood (similar to 7 y), as well as clinical growth measures obtained from after birth through midchildhood. We calculated sex specific birth length z scores for gestational age with the use of international reference data. We used mixed models with repeated length measures to predict individual length gain velocities for birth to <6 mo and 6 mo to 7 y of age, then used these velocities as outcomes in adjusted linear regression models with maternal protein intake as the main predictor. Results: Mean (range) second-trimester protein intake was 1.4 g . kg(-1) . d(-1) (0.3-3.1 g . kg(-1) . d(-1)). After adjusting for maternal sociodemographics, gestational weight gain, maternal and paternal height, and (for postdelivery outcomes) child sex, gestational age, and breastfeeding duration, each 1-SD (0.36 g . kg(-1) . d(-1)) increment in second-trimester protein intake corresponded to a-0.10 (95% CI:-0.18,-0.03) change in birth length z score, a-0.03 cm/mo (95% CI:-0.05,-0.01 cm/mo) change in slope of length growth from birth to <6mo, and a-0.09 cm/y (95% CI:-0.14,-0.05 cm/y) change in slope of length growth from 6 mo to midchildhood. Results were similar for first-trimester intake. Conclusions: In a population with relatively high protein intake during pregnancy, higher protein intake was associated with shorter offspring birth length and slower linear growth into midchildhood. Results suggest that higher protein intake during pregnancy does not increase fetal and child growth and may even reduce early length growth. Project Viva was registered at clinicaltrials.gov as NCT02820402.

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